Efficacy of Concentrated Platelets-Rich Fibrin versus Injectable Platelets Rich Fibrin on Gingival Thickness and Keratinized Tissue Width in Subjects with Thin Gingival Phenotype: Split-Mouth Randomized Clinical Trial

Background: Platelet-rich fibrin (PRF) has regenerative characteristics and is used as an autologous source of growth factors for tissue regeneration wound healing. Objective: Evaluating the efficacy C-PRF increasing gingival thickness (GT) keratinized width (KTW) in subjects with a thin phenotype comparison I-PRF injection. Methods: Ten healthy participants (GT ≤ 1.0 mm) were enrolled this study. The upper Lower arches participant’s mouth split into two sides, each side was randomly injected C-PRF, while contralateral I-PRF. GT KTW assessed before treatment, 1 month later, 3 months after last injection session. Results: Inter-group between groups revealed statistically significant difference at follow-up visit, mean ±1.373 mm effect size 0.200 p= 0.048. Intra-group both except group arch KTW, which non-significant 0.266. Conclusion: In individuals phenotypes, injections may influence increase KTW. results suggest that application be beneficial non-surgical method (ClinicalTrials.gov NCT05615155).